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Study to Assess the Feasibility of Stopping Prostate Cancer Treatment Early in Elderly Patients

Study to Assess the Feasibility of Stopping Prostate Cancer Treatment Early in Elderly Patients

Recruiting
70 years and older
Male
Phase N/A
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Overview

This study seeks to identify if it is feasible to stop Luteinizing Hormone-Releasing Hormone (LHRH) Agonist Therapy in elderly men with prostate cancer. We hypothesize that elderly prostate cancer patients on long term androgen ablation with LHRH agonists will be permanently castrated and do not require ongoing LHRH agonist therapy. Participants will be monitored by testosterone testing throughout study.

Eligibility

Inclusion Criteria:

  • Prostate cancer with >3 years of LHRH agonist therapy.
  • Age ≥70 years.
  • ECOG performance status ≤2
  • Baseline testosterone of < 20 ng/ml
  • No prior chemotherapy or Lu-PSMA (unless survival predictions are favorable).
  • Ability to understand and sign informed consent.

Exclusion Criteria:

  • none

Study details
    Elderly
    Prostate Cancer

NCT06824818

University of Chicago

15 June 2025

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