Overview
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS.
The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS.
Description
This project is the first of two projects. The second project will be registered as a separate project in the future and enroll participants from this project.
Eligibility
Inclusion Criteria:
- Participants should be in good health with normal or corrected-to-normal visual acuity
- Right handed
- No history of neurological disorder
- English speaker
- Able to provide written consent prior to admission
Exclusion Criteria:
- Left-handed
- Participants are pregnant, suspect pregnancy or are attempting to become pregnant
- Have a pacemaker, intracardiac lines or any other medically implanted device or medicine pump
- Have cochlear hearing implants
- Taking drugs known to influence neural receptors that facilitate neuroplasticity (see protocol)
- Have non removable body piercings or have foreign objects in body
- Have metal anywhere in the head that could increase risk of serious injury (not including braces, dental fillings, etc.) (see protocol)
- Have a personal or family history of seizure/epilepsy
- Taking prescription drugs that lower the threshold for seizures
- Recent history of excessive alcohol consumption
- History of alcohol addiction/dependence
- Recent history of recreational drug use
- History of drug addiction/dependence
- Recent history of recreational drug use
- History of drug addiction/dependence
- Diagnosed with a stroke, brain hemorrhage, brain tumor, encephalitis.
- Diagnosed with multiple sclerosis
- Diagnosed with Parkinson's disease or Alzheimer's disease
- Diagnosed with depression in the past 6 months
- Diagnosed with attention deficit disorder, schizophrenia, manic depressive (bipolar) disorder
- Diagnosed with normal pressure hydrocephalus or increased intra-cranial pressure
- Diabetes requiring insulin treatment
- Any serious heart disorder or liver disease