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N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma

N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma

Recruiting
18-19 years
All
Phase 2
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Overview

The purpose of this study is to find out whether N10 chemotherapy is a safe and effective treatment for children with high-risk neuroblastoma.

Eligibility

Inclusion Criteria:

  • Diagnosis of NB as defined by histopathology, BM metastases plus high urine catecholamine levels, or positivity in MIBG scan.
  • HR-NB, defined as MYCN-amplified stage L2/M/MS at any age and stage M in patients >18 months old.
  • No more than one prior cycle of HR-NB chemotherapy
  • Age <19 years.
  • Signed informed consent indicating awareness of the investigational nature of this treatment.

Exclusion Criteria:

  • Severe dysfunction of major organs, i.e., renal, cardiac, hepatic, neurologic, pulmonary, hematologic, or gastrointestinal toxicity > grade 2
  • Inability to comply with protocol requirements
  • Pregnancy

Study details
    High-risk Neuroblastoma
    Neuroblastoma
    Childhood Neuroblastoma

NCT06528496

Memorial Sloan Kettering Cancer Center

1 July 2025

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