Overview

The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).

Eligibility

Key Inclusion Criteria:

• Age 18 to 80, body weight ≥ 50 kg
• Has uncontrolled hypertension while receiving between 2 and 5 antihypertensive medications prescribed for hypertension
• Has mean office seated systolic blood pressure > 135 to ≤ 170 mmHg

Key Exclusion Criteria:

• Has known history of secondary hypertension
• Has documented history of poor adherence to antihypertensive medication
• Has unstable/underlying known cardiovascular disease
• Has abnormal thyroid function with clinical significance