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Real-world Effectiveness, Safety and Immunogenicity of Chikungunya Vaccination in Populations at Risk of Severe or Complicated Forms: Prospective Study in La Réunion

Recruiting
18 years of age
Both
Phase 4

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Overview

Against the backdrop of a growing chikungunya epidemic in La Réunion, this prospective study will assess the real-life efficacy, safety and immunogenicity of IXCHIQ® vaccine in vulnerable individuals (seniors, comorbid patients), defined by the French Health Autority (HAS) as at risk of severe or complicated forms and/or chronic disabling forms (chronic arthritis, chronic fatigue phenotypes). This study will also provide input for the preparation of a cluster randomized trial on a population scale.

Eligibility

Inclusion Criteria:

  • Eligible for anti-chikungunya vaccination according to french Health Authority (HAS)
  • Beneficiary of social security coverage
  • Signature of informed consent form

Exclusion Criteria:

  • Pregnant women
  • Vaccine contraindication for patients undergoing medical treatment
  • Persons under guardianship, curatorship or safeguard of justice
  • Anyone who has received immunoglobulin or a blood or plasma transfusion 3 months prior to vaccine administration

Study details

Chikungunya Virus Infection

NCT06928753

Centre Hospitalier Universitaire de la Réunion

2 May 2025

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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