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HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain

Recruiting
18 - 89 years of age
Both
Phase N/A

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Overview

The goal of this clinical trial is to examine the effect of rationale condition when taking open-label placebos on pain by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. We also aim to examine the effect of rationale condition on prescription opioid use by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other.

This study will include patients with chronic low back pain. The main question it aims to answer is:

How do rationales influence the effects of open-label placebos?

Researchers will compare different rationales given when taking an open-label placebo and a no-treatment group and a no rationale group taking OLPs.

Eligibility

Inclusion criteria are:

  • chronic pain (pain lasting at least 3 months, pain intensity 4/10 or over and interference 3/10 or over)
  • at least 18 years old
  • English speaking
  • have a smartphone or computer with video access
  • the chronic pain is concentrated into the patient's lower back (tentative criteria based on recruitment rate)

Exclusion Criteria

  • Have chronic pain because of a cancer diagnosis
  • Over 89 years of age
  • Suspect an allergy to any placebo ingredient
  • Currently receiving worker's compensation.

Study details

Chronic Low-back Pain, Chronic Pain

NCT06931158

Rhode Island Hospital

1 May 2025

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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