Image

Determination of the Optimal Volume of Liposomal Bupivacaine in Adductor Canal Block for Knee Joint Surgery

Determination of the Optimal Volume of Liposomal Bupivacaine in Adductor Canal Block for Knee Joint Surgery

Recruiting
18-65 years
All
Phase 4
  • Technical (Original)
  • Simplified (AI rewritten)

Powered by AI

Overview

Building on Bayesian design methodologies from volume optimization studies of ropivacaine in shoulder surgery, this study pioneers the application of a seamless dose-finding strategy in knee ACB. Utilizing advanced statistical models (BOIN/BOP2 design), we aim to systematically evaluate the volume-effect relationship of liposomal bupivacaine, providing precise dosing recommendations to advance personalized and optimized analgesic protocols for knee surgery.

Eligibility

Inclusion Criteria:

  • Patients undergoing elective general anesthesia for unilateral knee joint surgery.
  • Patients who provide informed consent.
  • Aged between 18 and 65 years old, regardless of gender.
  • American Society of Anesthesiologists (ASA) physical status classification of Ⅰ to Ⅲ
  • Body mass index (BMI) ≤ 35 kg/m².

Exclusion Criteria:

  • Femoral neuropathy.
  • Coagulation dysfunction.
  • Allergy to local anesthetics.
  • Infection at the puncture site.
  • History of chronic pain or opioid use.
  • Pregnancy.
  • Diabetes mellitus and peripheral neuropathy.

Study details
    Optimal Volume of Liposomal Bupivacaine

NCT06942689

Nanjing First Hospital, Nanjing Medical University

30 April 2025

Contact a study center
Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.