Overview
Building on Bayesian design methodologies from volume optimization studies of ropivacaine in shoulder surgery, this study pioneers the application of a seamless dose-finding strategy in knee ACB. Utilizing advanced statistical models (BOIN/BOP2 design), we aim to systematically evaluate the volume-effect relationship of liposomal bupivacaine, providing precise dosing recommendations to advance personalized and optimized analgesic protocols for knee surgery.
Eligibility
Inclusion Criteria:
- Patients undergoing elective general anesthesia for unilateral knee joint surgery.
- Patients who provide informed consent.
- Aged between 18 and 65 years old, regardless of gender.
- American Society of Anesthesiologists (ASA) physical status classification of Ⅰ to Ⅲ
- Body mass index (BMI) ≤ 35 kg/m².
Exclusion Criteria:
- Femoral neuropathy.
- Coagulation dysfunction.
- Allergy to local anesthetics.
- Infection at the puncture site.
- History of chronic pain or opioid use.
- Pregnancy.
- Diabetes mellitus and peripheral neuropathy.