Overview
The purpose of this study is to develop a single, standardized test to determine how individuals tolerate acute hypoxia in a stepwise fashion. We aim to evaluate the association between multiple factors, such as ventilatory compensation, heart rate response, acid-base changes, sex, pulmonary function, etc, which may explain why some individuals tolerate exercise in hypoxia better than others. Identifying these factors of association will inform future pharmacological and non-pharmacological attempts to combat acute hypoxic exercise.
Eligibility
Inclusion Criteria:
• Physically active (≥150 minutes of moderate physical activity per week)
Exclusion Criteria:
- Contraindications to exercise testing
- Currently pregnant
- Musculoskeletal or metabolic disease
- Allergies to lidocaine
- Body-mass index ≤18 or ≥35 kg·m-2
- Pacemaker
- No confounding cardiorespiratory disease
- Persistent tobacco use (>15 pack years)