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Effectiveness of Midodrine as an Adjuvant to Norepinephrine in Weaning Critically Ill Patients From Vasopressors

Effectiveness of Midodrine as an Adjuvant to Norepinephrine in Weaning Critically Ill Patients From Vasopressors

Recruiting
18 years and older
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

This study aims to evaluate the effectiveness of midodrine as an adjuvant to norepinephrine in weaning critically ill patients from vasopressors

Eligibility

Inclusion Criteria:

  • Patients with refractory hypotension on an intravenous vasopressor for more than 24 h but deemed clinically stable.
  • Patients on noradrenaline support <10 μg/min

Exclusion Criteria:

  • Known allergy to midodrine.
  • Severe shock state, as evidenced by multiple vasopressor infusions or high vasopressor requirement (i.e. noradrenaline >10 μg/min)
  • Patients with severe organic heart disease (e.g., heart failure, sever aortic stenosis), pregnancy, thyrotoxicosis or pheochromocytoma.
  • Those with no enteral route available.

Study details
    Shock

NCT06930235

Sohag University

25 April 2025

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