Overview
Women with a severely diminished ovarian reserve and monofollicular growth are at a higher risk of premature ovulation as well as poor quality oocytes. Our group showed previously that women with severely diminished ovarian reserve benefit from receiving the final oocyte maturation at smaller follicle sizes in terms of reducing the risk of premature ovulation and finding mature oocytes even out of small size follicles.
Adding the measurement of the follicular volume at the time of final oocyte maturation might provide more information on the proper timing of trigger administration compared to the follicular size alone, hormonal profile as well as previous stimulation attempts. Setting a cutoff value of follicular volume for trigger might help to avoid premature ovulation and possibly increase the chances of ending up with a euploid embryo.
Eligibility
Inclusion Criteria:
- Reproductive age group: 18 -48
- undergoing ovarian stimulation for oocyte vetrification
- undergoing IVF/ ICSI with PGT-A / PGT-M / PGT- Sr
- less than or equal to 3 AFC on initiation of stimulation
- follicular phase stimulation
Exclusion Criteria:
- surgically retrieved sperm