Overview
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.
Eligibility
Inclusion Criteria:
- Healthy on the basis of medical history and limited physical examination.
- Current regular user of E-Cigarettes (≥ 15 days in the past 30 days)
Exclusion Criteria:
- • Medications
- Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rifampicin, carbamazepine, phenobarbital, and other anticonvulsant drugs).
- Use of sympatholytic medications for cardiovascular conditions including hypertension (Example: beta and alpha-blockers).
- Concurrent use of nicotine-containing medications (Example: nicotine patch, lozenge, gum).
- Any stimulant medications (example: Adderall) generally given for ADHD
treatment.
• Pregnancy
- Pregnancy (self-reported and urine pregnancy test)
- Breastfeeding (determined by self-report)
- Women of childbearing potential must be using an acceptable method of
contraception
- Inability to read and write in English
- A known propylene glycol/vegetable glycerin allergy
- Uncomfortable with getting blood drawn