Overview
The proposed research is a parallel arm, randomized placebo-controlled clinical trial designed to assess changes in muscle strength, volume, fatigue resistance, and mobility in older adults after daily consumption of 12g of linoleic acid-rich oil.
Description
Study Objectives
- To assess the effect of linoleic acid supplementation on muscle strength, muscle volume, fatigue- resistance, and physical mobility.
- To quantify the impact of linoleic acid supplementation on cardiolipin species and mitochondrial function in skeletal muscle of older adults
Eligibility
Inclusion Criteria:
- Linoleic Acid Intake <75% of the adequate intake
- Probable sarcopenia
Exclusion Criteria:
- Gastrointestinal diseases or disorders (including pancreatic and gastric bypass surgery) where consumption of the study foods would be contraindication or where the disease or disorder could negatively affect nutrient absorption and/or would prevent participants from tolerating the study foods
- Hyperthyroidism diagnosis
- Food Allergy or intolerances
- Any dietary restriction where consumption of the study foods or any ingredient would be contraindicated
- Unstable management of heart failure, heart disease events (including stroke or heart attack) within last 3 months prior to enrollment, a plan for heart surgeries or cardiac procedures
- Current or previous diagnosis of severe kidney failure, liver cirrhosis, other liver diseases/infections that cause liver damage and some pulmonary diseases or severe/uncontrolled pulmonary diseases
- Severe or uncontrolled rheumatologic or orthopedic diseases
- Current diagnosis of or current treatment of cancer other than non-melanoma skin cancer
- Neuromuscular or neurological conditions or diseases or use of mobility assistance (wheelchair, walker etc..) that would impact movement needed to perform the muscle function tests or prevent completion of the muscle function tests
- Use of mobility assistance (wheelchair, walker etc..) that would prevent completion of the muscle function tests
- Current use of supplements or medications for weight loss or following a weight loss program
- Use of supplements high in linoleic acid in the past 4 weeks prior to enrolling
- Pregnancy and lactation
- Alcohol or drug abuse
- Allergy/intolerance to lidocaine or similar medication
- Use of anticoagulant, antiplatelet, or other blood thinner medications
- Terminal Illness
- Any condition leading to muscle loss or weakness, impaired mobility or range of motion in legs (excluding normal aging)