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Risk Factors for Sub Mucosal Fibrosis During Achalasia Cardia: A Prospective Study

Risk Factors for Sub Mucosal Fibrosis During Achalasia Cardia: A Prospective Study

Recruiting
18-75 years
All
Phase N/A

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Overview

Classification for Stasis Esophagitis:

Grade I Grade II Grade III Vascular pattern Obscured Obscured Obscured Mucosal thickening No Yes Yes Ulceration No Yes Yes Nodularity No No Yes

Description

Predictors of Submucosal Fibrosis:

Various factors were analysed for prediction of SMF including age, gender, stasis esophagitis, type of achalasia, duration of disease, lower esophageal sphincter pressure (LESP), height of barium column on barium esophagogram and severity of symptoms (Eckardt score). Esophageal mucosa was graded for the severity of stasis esophagitis (grade I to grade III) based on vascular pattern, mucosal thickening, ulceration and nodularity. SMF was graded (I minimal, II moderate, III severe) according to mucosal lift, difficulty in entry, density of SM fibers, separation of mucosa and muscle.

Eligibility

Inclusion Criteria:

  • Patients (between 18 to 75 years of age) who underwent POEM for achalasia or other esophageal motility disorders.
  • Had a diagnosis of esophageal achalasia confirmed by High Resolution Manometry, barium esophagogram.

Exclusion Criteria:

  • Patients who underwent treatment other than achalasia
  • Lost to follow up patients.
  • Incomplete clinical record patients
  • Patients not willing to participate in the study

Study details
    Esophagus Disorder

NCT06815341

Asian Institute of Gastroenterology, India

3 April 2025

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