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Brachial Plexus Nerve Block Versus Haematoma Block for Closed Reduction of Distal Radius Fracture in Adults - The BLOCK Trial. A Multicentre Randomised Controlled Trial.

Brachial Plexus Nerve Block Versus Haematoma Block for Closed Reduction of Distal Radius Fracture in Adults - The BLOCK Trial. A Multicentre Randomised Controlled Trial.

Recruiting
18 years and older
All
Phase 4

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Overview

The aim of the project is to evaluate the beneficial and harmful effects of an ultrasound-guided brachial plexus nerve block for patients with a distal radius (wrist) fracture in the need of realignment of fractured bone endings without cutting the skin (closed reduction), in comparison to a haematoma block, which is standard care in Denmark.

Every participant will receive one of the following types of anaesthesia for the realignment of the wrist fracture:

  1. A nerve block of the arm (plexus brachialis block)
  2. A haematoma block, which is the current standard anaesthesia in the emergency departments.

Eligibility

Inclusion Criteria:

  • Adults (age ≥ 18 years) with a distal radius fracture in need of closed reduction

Exclusion Criteria:

  • Patients who would never qualify for surgery according to local guidelines
  • Lack of informed consent
  • No Danish Central Person Register (CPR) number
  • Allergies to the trial medication
  • Distal radius fracture initially deemed to require surgery regardless of the outcome of the closed reduction
  • Open fractures (fracture-related wound requiring sutures)
  • Other fractures on the same extremity ((NOT including distal ulna fracture(s))
  • Bilateral distal radius fractures both requiring closed reduction
  • Concomitant medical or surgical condition taking priority over the closed reduction of the distal radius fracture.

Study details
    Distal Radius Fractures
    Fracture Dislocation
    Fracture Dislocation of Upper Limb Joint
    Colles' Fracture
    Closed Reduction of Fracture and Application of Plaster Cast

NCT06678438

Nordsjaellands Hospital

21 June 2025

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