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Identifying and Treating Depression in the Orthopaedic Trauma Population

Identifying and Treating Depression in the Orthopaedic Trauma Population

Recruiting
18 years and older
All
Phase 4

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Overview

The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are:

  1. What are the outcomes of patients who screen positive for depressive symptoms and are prescribed either an Selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI).
  2. What are the outcomes of patients who screen positive for depressive symptoms and choose not to pursue treatment with medication?

Description

Depression is common among orthopaedic trauma patients and associated with worsened outcomes including pain, opioid consumption, patient-reported outcomes ,complications, and length of stay. Addressing depression, therefore, should lead to improved outcomes. Orthopaedic surgeons may believe treating depression is outside their scope or that they lack tools to address depressive symptoms. In fact, only 45% of surgeons report they are likely to screen patients, and only 27% are likely to refer patients for psychological treatment.

Eligibility

Inclusion Criteria:

  • Patients presenting to an Orthopaedic trauma clinic for the first time following operative extremity fracture or any pelvis fracture
  • A score of greater than or equal to 5 on the Patient Health Questionnaire-9 (PHQ-9) at first post- operative visit
  • Age 18 or older
  • Speak English or Spanish

Exclusion Criteria:

  • Currently taking medication to treat depression
  • Contraindication/allergy to one of the study medications
  • Bipolar disorder of psychotic disorder
  • Endorse suicidal ideation

Study details
    Depression

NCT05976347

Wake Forest University Health Sciences

3 August 2025

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