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Nasal vs Oral Breathing in Drug Induced Sleep vs Natural Sleep

Nasal vs Oral Breathing in Drug Induced Sleep vs Natural Sleep

Recruiting
18 years and older
All
Phase N/A

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Overview

This project will provide important new information regarding (1) the relationship between route of breathing and airway collapsibility and (2) whether route of breathing during DISE (Drug-Induced Sleep Endoscopy) is representative of natural sleep.

Description

As part of standard of care, a drug-induced sleep endoscopy will be done, where route of breathing will be determined as a percentage of total breaths (during baseline, lateral sleep and maneuver). As part of the research procedure, an in-laboratory Polysomnogram will be conducted as study procedure including a oronasal pressure signal cannula to assess route of breathing.

Eligibility

Inclusion Criteria:

  • • Adults (≥ 18yrs) that underwent clinical evaluation at the CPAP Alternatives Clinic at Penn Otorhinolaryngology.
    • Must have at least mild OSA (AHI>5)

Exclusion Criteria:

  • • Sleep study with an AHI<5, >25% of total events being central or mixed events, or inability to achieve adequate drug-induced sleep.
    • Upper Respiratory Illness at the time of the DISE.

Study details
    Sleep Apnea
    Obstructive

NCT06789770

University of Pennsylvania

1 April 2025

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