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Investigating the Impact of Duration and Amount of Light on the Circadian System Response - Aim 3

Investigating the Impact of Duration and Amount of Light on the Circadian System Response - Aim 3

Recruiting
55 years and older
All
Phase N/A

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Overview

Investigate the long-term impact of amount and duration of Tailored Lighting Intervention (TLI) obtained from Aims 1 and 2 on sleep, cognition, circadian marker, mood, and behavior in AD/ADRD patients. For this single-arm, randomized, placebo-controlled study, the researchers plan to recruit 100 participants who will experience either the active TLI or the placebo for 6 months.

Eligibility

Inclusion Criteria:

  • Diagnosis of Alzheimer's disease or related dementia with a Montreal Cognitive Assessment score <25
  • Sleep disturbance with a Pittsburgh Sleep Quality Index score ≥5

Exclusion Criteria:

  • Extensive brain vascular disease, traumatic brain injury, multiple sclerosis, Parkinson's Disease
  • Obstructing cataracts
  • Severe macular degeneration
  • Use of sleep medication
  • Use of oral melatonin
  • untreated moderate to severe sleep apnea
  • Severe restless leg syndrome - Blindness

Study details
    Alzheimer's Disease
    Mild Cognitive Impairment

NCT06595030

Icahn School of Medicine at Mount Sinai

9 June 2025

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