Overview
This study aims to examine the effects of Low-Intensity Focused Ultrasound (LIFU) on brain activity in patients with alcohol use disorder.
Description
This is a single-center, double-blind, controlled, randomized, complete block, 2-period crossover pilot trial. The study will assess target engagement of the ventral striatum after LIFU in patients with alcohol use disorder using resting state and task-based functional magnetic resonance imaging (fMRI).
Eligibility
Inclusion Criteria:
- Male or female ≥ 18 years of age.
- Documentation of an AUD diagnosis per DSM-5 criteria as evidenced by problematic pattern of alcohol use leading to clinically significant impairment or distress, as manifested by at least two of the DSM-5 criteria, occurring within a 12-month period.
- Be willing to undergo a brain MRI and follow study protocol.
Exclusion Criteria:
- Pregnant or breastfeeding.
- Presence of a condition or abnormality that would compromise the safety of the patient or the quality of the data.
- Non-English speaking.
- Other investigational AUD treatments.
- Primary psychosis, Bipolar I, or severe personality disorder.
- Active suicidality or history of suicide attempt in the past 5 years.
- Cognitive impairment (MoCA <24)
- Significant medical or neurological disease, or life expectancy <12 mos.
- Significant brain abnormality on brain imaging.
- Any MRI exclusion criteria.