Overview
In this prospective, randomized, split-body control trial, we aim to compare complications, patient-reported outcomes, and cost differentials following reduction mammaplasty with prophylactic closed incision negative pressure wound therapy versus standard adhesive dressing.
Eligibility
Inclusion Criteria:
- Female patients
- Age 18 years or older
- Scheduled to undergo bilateral reduction mammaplasty with a Wise pattern (anchor) incision and a superomedial, inferior, or central mound pedicle at MedStar Georgetown University Hospital or MedStar Good Samaritan Hospital
- Able to comply with study procedures and follow-up visits
Exclusion Criteria:
- Younger than 18 years of age
- Biologically male patients
- Scheduled to undergo unilateral breast mammaplasty
- Currently pregnant or lactating
- Use of steroids or other immune modulators known to affect wound healing
- Current smokers who have not paused for a minimum of 4 weeks prior to surgery
- History of breast cancer
- History of oncologic or reconstructive breast surgery
- History of radiation to the breast
- History of chemotherapy or hormone therapy
- Tattoos in the area of skin incision
- Skin conditions known to affect wound healing or scarring of the breast (e.g., cutis laxa)
- Significant history of scar problems (e.g., hypertrophic scarring or keloids) post-surgical incisions with active bleeding
- Exposure of blood vessels, organs, bone, or tendon at the base of the reference wound
- Known allergies to product components (e.g., medical or NPWT tape)
- Unable to comply with NPWT requirements, including those unable to present for postoperative follow-up
- Lactating at the time of surgery
- Require deviation from standard operative or closure techniques (e.g., staples, free nipple grafts)
- Considered part of a vulnerable population (adults unable to consent, infants, children, teenagers, pregnant women, prisoners)
- Experience intraoperative complications due to surgical complications not related to the NPWT instrumentation (e.g., expanding hematoma)