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Single and Multiple Ascending Dose Study of AMG 513 in Participants With Obesity

Single and Multiple Ascending Dose Study of AMG 513 in Participants With Obesity

Recruiting
18-65 years
All
Phase 1
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

The primary objective of this study is to assess the safety and tolerability of AMG 513 after single and multiple doses.

Eligibility

Inclusion Criteria:

  • Participants in the study will be males and females 18 to 65 years of age at the time of signing the informed consent with a body mass index (BMI) between ≥ 30 kg/m^2 and ≤ 40 kg/m^2.
  • Females enrolled must be of non-childbearing potential.

Exclusion Criteria:

  • History and/or clinical evidence of diabetes mellitus, including hemoglobin A1c ≥ 6.5% and/or a fasting glucose of ≥ 126 mg/dL (7 mmol/L) at screening.
  • Triglycerides ≥ 5.65 mmol/L (i.e., 500 mg/dL) at screening.

Study details
    Cardiometabolic Disease

NCT06585462

Amgen

6 May 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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