Overview
We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.
Eligibility
Inclusion Criteria:
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- Males and females ages 40-60 years.
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2. BMI 25 to ≤40 kg/m2 (or body fat % ≥25% in males or ≥36% in females)
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3. Capable of providing informed consent.
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4. COVID-19 negative and/or asymptomatic.
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5. Willing to abstain from drinking alcohol or consuming marijuana and CBD
products during the 4-day study meal period
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6. HbA1c: 5.7-6.4%
Exclusion Criteria:
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- Participant who does not/will not eat animal protein sources.
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2. Allergy to wheat, soy, or common ingredients in plant-based protein products.
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3. Body mass index <25 kg/m2 or >40 kg/m2.
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4. Hemoglobin <10g/dL at screening.
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5. Platelets <150,000/uL at screening.
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6. History of chemotherapy or radiation therapy for cancer in the 6 months prior
to enrollment.
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7. History of gastrointestinal bypass/reduction surgery.
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8. Pregnant or lactating individuals.
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9. History of a chronic inflammatory disease (e.g. Lupus, Crohn's disease)
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10. Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I)
therapy.
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11. Currently using prescription blood thinning medications.
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12. Currently using corticosteroid medications (cortisone, hydrocortisone,
prednisone, etc.).
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13. Unable or unwilling to suspend aspirin use for 7 days prior to Visit 3 and
Visit 7.
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14. Unwilling to avoid using protein or amino-acid supplements during
participation.
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15. Unwilling to fast overnight.
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16. Unwilling to avoid alcohol, marijuana and CBD products for the four study days.
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17. Participants on glucagon-like-peptide-1 receptor agonist (GLP-1-RA) medications
for <3 months or with less than one treatment dose (injection) every two weeks