Overview
The goal of this clinical trial is to learn if continuous glucose monitoring works to treat postprandial hypoglycaemia in patients who have undergone bariatric surgery. The main question it aims to answer is:
• Is continuous glucose monitoring superior to usual care for prevention of postprandial hypoglycaemia in patients with verified postprandial hypoglycaemia after bariatric surgery?
Researchers will compare continuous glucose monitoring to usual care to see if continuous glucose monitoring works to treat postprandial hypoglycaemia.
Participants will:
- Use a continuous glucose monitor for 5 weeks or use no continuous glucose monitor for 5 weeks. During week 6 both groups will wear a continuous glucose monitor, but the patients who have not been wearing a continuous glucose monitor will wear a blinded continuous glucose monitor.
- Visit the clinic 3 times.
- Register symptoms of hypoglycaemia, answer questionnaires, keep a food diary, measure weight and body composition and take blood samples.
Eligibility
Inclusion Criteria:
- Gastric bypass surgery at least 1 year ago
- Age ≥18 years
- Symptomatic postprandial hypoglycaemia; capillary glucose level <3.0 mmol/L 1-4 hours after meals
Exclusion Criteria:
- Not able to give informed consent
- Reduced compliance due to severe mental and psychiatric conditions
- Use of insulin or sulfonylureas
- Use of systemic corticosteroids
- Primary or secondary adrenal insufficiency
- Insulinoma
- Severe heart-, lung, liver- or kidney disease, cancer, malnutrition and other medical conditions causing fragility
- Performed bariatric revisional surgery
- Drug- or alcohol abuse
- Pregnancy
- Use of acarbose or octreotide in the treatment of postprandial hypoglycemia
- Use of continuous glucose monitor