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Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries

Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries

Recruiting
18 years and older
All
Phase N/A
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Overview

Around 10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA) which pathophysiology is often uncertain. The aim of the study is to evaluate inflammation and endothelial dysfunction biomarkers in MINOCA patients during both acute and stable phases, comparing them with those with MI and obstructive coronary arteries (MICAD).

Description

Prospective observational study in patients with Myocardial Infarction (MI) divided into two groups: MI with obstructive coronary arteries (MICAD) and MI with non-obstructive coronary arteries (MINOCA). Levels of interleukin-6, tumor necrosis factor-alpha, high-sensitivity Creactive protein, and asymmetric dimethylarginine will be determined at three time points: within the 24 hours from the onset of pain, discharge, and two months after MI. The association of biomarkers, normalized by peak troponin value, with the risk of MINOCA will be evaluated using logistic regression.

Eligibility

Inclusion Criteria:

  • Patients admitted with Myocardial Infarction and undergo a coronariography
  • Patients must sign informed consent.

Exclusion Criteria:

  • Patients who don´t sign informed consent

Study details
    Myocardial Infarction
    MINOCA
    Inflammation
    Biomarkers
    Endothelial Dysfunction

NCT06446895

Hospital Universitario Getafe

11 June 2024

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