Overview

To look at the effectiveness of the combination of pembrolizumab, carboplatin, and paclitaxel in participants with stage 1 cT1b-T1cN0M0 Triple Negative Breast Cancer.

Eligibility

Inclusion Criteria:

        Participants are eligible to be included in the study only if all of the following criteria
        apply:
          1. Participants must have histologically confirmed ER negative, PR negative and
             HER2-negative (TNBC) defined as ER<10%, PR<10%, and HER2 negative (per 2018 ASCO CAP
             guidelines). All pathology will be confirmed at the MD Anderson Houston Campus.
             Participants with tumors designated as HER2 equivocal (per ASCO CAP guidelines) are
             eligible if in view of treating physician patient is not considered a candidate for
             HER2-targeted therapy. Participants with weakly ER or PR positive disease, defined as
             ER and/or PR between 1-9% by immunohistochemistry, are eligible if the treating
             physician considers the participants not eligible for adjuvant endocrine therapy.
          2. AJCC 8 anatomic tumor Stage 1 T1b-T1c, N0, M0. All participants with clinically
             suspicious nodes must undergo core or fine needle biopsy per standard clinical
             practice to pathologically assess at least 1 suspicious index node. Participants with
             suspicious nodes that are biopsy negative will be eligible.
          3. Male/female participants who are at least 18 years of age on the day of signing
             informed consent with histologically confirmed diagnosis of Stage 1 T1b-T1cN0M0 TNBC
             will be enrolled in this study.
          4. Male participants: A male participant must agree to use a contraception as detailed in
             Appendix 2 of this protocol during the treatment period and for at least 120 days,
             corresponding to time needed to eliminate any study treatment(s) (e.g. 5 terminal
             half-lives for pembrolizumab and/or any active comparator/combination) plus an
             additional 90 days (a spermatogenesis cycle) for study treatments with evidence of
             genotoxicity at any dose after the last dose of study treatment and refrain from
             donating sperm during this period.
          5. Female participants: A female participant is eligible to participate if she is not
             pregnant (see Appendix 2), not breastfeeding, and at least one of the following
             conditions applies:
               1. Not a woman of childbearing potential (WOCBP) as defined in Appendix 2 OR
               2. A WOCBP who agrees to follow the contraceptive guidance in Appendix 2 during the
                  treatment period and for at least 120 days (corresponding to time needed to
                  eliminate any study treatment(s) (pembrolizumab and/or any active
                  comparator/combination) plus 30 days (a menstruation cycle) for study treatments
                  with risk of genotoxicity after the last dose of study treatment.
          6. Participants who have AEs due to previous anticancer therapies must have recovered to
             ≤Grade 1 or baseline. Participants with endocrine-related AEs who are adequately
             treated with hormone replacement or participants who have ≤Grade 2 neuropathy are
             eligible.
          7. The participant provides written informed consent for the trial.
          8. Archival tumor tissue sample or newly obtained [core, incisional or excisional] biopsy
             of a tumor lesion not previously irradiated has been provided. Formalin-fixed,
             paraffin embedded (FFPE) tissue blocks are preferred to slides. Newly obtained
             biopsies are preferred to archived tissue.
          9. Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1
             (appendix 3). Evaluation of ECOG is to be performed within 7 days prior to the first
             dose of study intervention.
         10. Have adequate organ function as defined in the following table (Table 3). Specimens
             must be collected within 10 days prior to the start of study intervention.
         11. Non-English speaking participant can enroll in the study as long as they speak a
             language for which interpretation can be provided by a licensed interpreter either in
             person or virtually.
         12. Criteria for known HIV positive participants.
               1. Participants with HIV are eligible if they have well-controlled HIV with negative
                  viral load on ART and must not have had any AIDS-defining opportunistic
                  infections within the past 12 months from initiation of C1D1 study treatment.
               2. HIV screening tests are not required unless:
             i. Known history of HIV ii. As mandated by local health authority
         13. Criteria for known Hepatitis B and C positive participants Hepatitis B and C screening
             tests are not required unless:
               -  Known history of HBV or HCV infection
               -  As mandated by local health authority 13.1 Hepatitis B positive Participants
               -  Participants who are HBsAg positive are eligible if they have received HBV
                  antiviral therapy for at least 4 weeks and have undetectable HBV viral load prior
                  to randomization.
               -  Participants should remain on anti-viral therapy throughout study intervention
                  and follow local guidelines for HBV anti-viral therapy post completion of study
                  intervention. 13.2 Participants with history of HCV infection are eligible if HCV
                  viral load is undetectable at screening.
               -  Participants must have completed curative anti-viral therapy at least 4 weeks
                  prior to randomization.
        Table 3 Adequate Organ Function Laboratory Values System Laboratory Value Hematological
        Absolute neutrophil count (ANC) = ≥1500/µL Platelets = ≥100 000/µL Hemoglobin = ≥9.0 g/dL
        or ≥5.6 mmol/La Renal Creatinine OR Measured or calculatedb creatinine clearance (GFR can
        also be used in place of creatinine or CrCl) = ≤1.5 × ULN OR ≥30 mL/min for participant
        with creatinine levels >1.5 × institutional ULN Hepatic Total bilirubin = ≤1.5 ×ULN OR
        direct bilirubin ≤ULN for participants with total bilirubin levels >1.5 × ULN AST (SGOT)
        and ALT (SGPT) = ≤2.5 × ULN (≤5 × ULN for participants with liver metastases) Coagulation
        International normalized ratio (INR) OR prothrombin time (PT) Activated partial
        thromboplastin time (aPTT) = ≤1.5 × ULN unless participant is receiving anticoagulant
        therapy as long as PT or aPTT is within therapeutic range of intended use of anticoagulants
        ALT (SGPT)=alanine aminotransferase (serum glutamic pyruvic transaminase); AST
        (SGOT)=aspartate aminotransferase (serum glutamic oxaloacetic transaminase); GFR=glomerular
        filtration rate; ULN=upper limit of normal. a Criteria must be met without erythropoietin
        dependency and without packed red blood cell (pRBC) transfusion within last 2 weeks. b
        Creatinine clearance (CrCl) should be calculated per institutional standard. Note: This
        table includes eligibility-defining laboratory value requirements for treatment; laboratory
        value requirements should be adapted according to local regulations and guidelines for the
        administration of specific chemotherapies.
        Exclusion Criteria:
        Participants are excluded from the study if any of the following criteria apply:
          1. Stage 2, 3 or 4 Triple negative breast cancer
          2. Hormone Receptor positive and/or Human Epidermal Growth factor 2 (HER 2) positive
             breast cancer
          3. A WOCBP who has a positive urine pregnancy test within 72 hours prior to dose of study
             drug (see Appendix 2). If the urine test is positive or cannot be confirmed as
             negative, a serum pregnancy test will be required.
          4. Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent or with
             an agent directed to another stimulatory or co-inhibitory T-cell receptor (eg, CTLA-4,
             OX-40, CD137).
          5. Has received prior systemic anti-cancer therapy including investigational agents
             within 4 weeks to allocation of therapy.
          6. Has received prior radiotherapy within 2 weeks of start of study intervention or
             radiation-related toxicities requiring corticosteroids. Note: Two weeks or fewer of
             palliative radiotherapy for non-CNS disease, with a 1-week washout, is permitted.
          7. Has received a live vaccine or live-attenuated vaccine within 30 days before the first
             dose of study intervention. Administration of killed vaccines is allowed.
          8. Has received an investigational agent or has used an investigational device within 4
             weeks prior to study intervention administration.
          9. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
             (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
             immunosuppressive therapy within 7 days prior to the first dose of study drug.
         10. Known additional malignancy that is progressing or has required active treatment
             within the past 3 years. Note: Participants with basal cell carcinoma of the skin,
             squamous cell carcinoma of the skin or carcinoma in situ, excluding carcinoma in situ
             of the bladder, that have undergone potentially curative therapy are not excluded.
         11. Has known active CNS metastases and/or carcinomatous meningitis.
         12. Has severe hypersensitivity (≥Grade 3) to any of the components or any of its
             excipients used in the study treatments.
         13. Has active autoimmune disease that has required systemic treatment in the past 2 years
             except replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid)
         14. Has a history of (non-infectious) pneumonitis/interstitial lung disease that required
             steroids or has current pneumonitis/interstitial lung disease.
         15. Has an active infection requiring systemic therapy for >14 days from initiation of
             C1D1 study treatment.
         16. Concurrent active Hepatitis B (defined as HBsAg positive and/or detectable HBV DNA)
             and Hepatitis C virus (defined as anti-HCV Ab positive and detectable HCV RNA)
             infection. Note: Hepatitis B and C screening tests are not required unless:
               -  Known history of HBV and HCV infection
               -  As mandated by local health authority
         17. Has not adequately recovered from major surgery or has ongoing surgical complications.
         18. Has a history or current evidence of any condition, therapy, or laboratory abnormality
             or other circumstance that might confound the results of the study, interfere with the
             participant's participation for the full duration of the study, such that it is not in
             the best interest of the participant to participate, in the opinion of the treating
             investigator.
         19. Has known psychiatric or substance abuse disorders that would interfere with
             cooperation with the requirements of the trial.
         20. Is pregnant or breastfeeding or expecting to conceive or father children within the
             projected duration of the study, starting with the screening visit through 120 days
             after the last dose of trial treatment.
         21. Has had an allogenic tissue/solid organ transplant.
         22. Participants with the following contraindications to doxorubicin therapy: recent
             myocardial infarction; severe myocardial insufficiency; severe arrhythmias; previous
             treatment with complete cumulative doses of doxorubicin, daunorubicin, idarubicin,
             and/or other anthracyclines and anthracenedione.