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Effect of Letermovir Prophylaxis on CMV-specific Immune Reconstitution Post UCBT

Effect of Letermovir Prophylaxis on CMV-specific Immune Reconstitution Post UCBT

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Overview

To explore the effect of letermovir prophylaxis on cytomegalovirus-specific immune reconstitution post unrelated cord blood transplantation

Description

To explore the effect of letermovir prophylaxis on cytomegalovirus-specific and other lymphocyte subsets immune reconstitution post unrelated cord blood transplantation, and to analyze the potential mechanism and risk factors of late CMV reactivation after letermovir discontinuation.

Eligibility

Inclusion Criteria:

  • Patients are receiving a first unrelated cord blood transplantation (UCBT).
  • Patients start letemovir prophylaxis within 0-28 days post UCBT.

Exclusion Criteria:

  • Patients having active CMV DNAemia at the time of letermovir initiation.
  • Patients recruited in a clinical study on an anti-CMV trial.

Study details
    Cytomegalovirus Infection Reactivation

NCT06441669

Anhui Provincial Hospital

7 June 2024

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