Overview
This clinical trial aims to explore the effect of Vitamin B6 supplementation on pain thresholds and tolerance in healthy adults using thermal and electrical stimulation. Researchers will compare a placebo group to high-dose Vitamin-B6 to see if vitamin B6 increases pain thresholds and tolerance.
Description
The main questions it aims to answer are:
- How does vitamin B6 affect pain thresholds and tolerance following a single 100mg dose?
- How does vitamin B6 affect pain thresholds following daily supplementation for up to a month?
- Does vitamin B6 supplementation affect measures related to the experience of pain, such as state anxiety, sleep, diet, and mood at different time points
Eligibility
Inclusion Criteria:
- Over the age of 18 years
- Fluent speaker of English language
Exclusion Criteria:
- Under 18 years
- Presence or history of chronic pain
- Presence of neuropathic/nerve pain
- Raynaud's syndrome
- Using any vitamin supplementations that contain Vitamin B6 at more than the RDA, or combinations of B vitamins.
- On any medication that is GABA agonistic
- Any use of analgesic/anti-inflammatory medication up to 48 hours prior to any of the testing sessions.
- Any heart conditions
- Newly acquired tattoos on the pain stimulation site