Overview
This project aims to develop and validate a model of human organoids derived from patients with Spondyloarthritis, focusing on synovial and intestinal tissues as targets of the gut-joint axis. The tissue marker profile of patient-derived organoids studied by gene expression, immunohistochemistry, and cytokine production profile will be compared with that of controls in order to test for the presence of specific biomarkers.
Eligibility
Inclusion Criteria:
- More than 18 years of age;
- Ability to understand and sign an informed consent form;
- Clinical indication for intestinal and/or synovial biopsy;
- Only for SpA patients group: meeting ASAS classification criteria.
Exclusion Criteria:
- Actively treated cancer;
- Severe comorbidities that, in the investigator's opinion, may affect the quality of samples for planned experimental applications;
- Only for patients undergoing ileal-colic biopsy: history of colorectal cancer disease, celiac disease;
- Only for patients undergoing a synovial biopsy: septic arthritis.