Overview
This study aims to conduct a detailed analysis of the immunological response profiles that emerge at different clinical stages of medication-related osteonecrosis of the jaw (MRONJ). The research seeks to understand how these responses influence the pathogenesis, staging, and treatment of MRONJ. Throughout the study, cytokine levels, inflammation markers, and other immunological parameters observed at various stages will be comprehensively assessed. The results of these analyses are expected to provide insights into how stage-specific immunological variables could play a role in the diagnosis and treatment of MRONJ.
Eligibility
Inclusion Criteria:
- Individuals aged 18 and over
- Both male and female participants
- Individuals who apply to the Oral and Maxillofacial Surgery Clinic at Marmara University Faculty of Dentistry due to medication-related osteonecrosis of the jaw during the study period
- Individuals or their legal representatives who have provided written consent to participate in the study
Exclusion Criteria:
- Non-drug-related osteonecrosis/osteomyelitis
- Osteoradionecrosis
- Metastasis to the oral region
- Individuals who have not given written consent to participate in the study