Overview
To validate a new method for assessing perioperative risk in the cancer patient undergoing major cancer surgery.
In this proposed study researchers will:
- Measure preoperative energy reserve capacity (fitness)
- Determine if postoperative morbidity is a function of perioperative cardiopulmonary gas exchange metabolism
Description
Primary Objective:
• To characterize the effects of neoadjuvant therapy (chemotherapy, radiation therapy, and/or immunotherapy) on functional capacity in esophageal and lung cancer participants as measured by gas exchange parameters (%predicted AT, %predicted P-VO2, VO2 at AT & peak exercise, oxygen pulse, ΔVO2/ΔWR, ΔVE/ΔVCO2) obtained from CPET before and after neoadjuvant therapy.
Secondary Objectives:
• To characterize changes in CPET measures in participants treated with chemotherapy, radiation therapy, and/or immunotherapy followed by surgery and correlate these changes with postoperative outcome.
Eligibility
Inclusion Criteria:
- Participants 18 years of age or older.
- Participants with newly diagnosed esophageal and lung cancer undergoing neoadjuvant chemotherapy, radiation therapy, and/or immunotherapy.
- Participants who have signed the consent form to participate in the study.
- Participants must have been evaluated in the Perioperative Evaluation and Management (POEM) Center or by a staff Anesthesiologist.
- All laboratory and diagnostic evaluations required or used to evaluate the patient must be completed. All participants must be approved to undergo anesthesia by the standards of the POEM Center.
- No samples belonging to vulnerable populations (children, pregnant women, cognitively impaired adults or prisoners) will be allowed from participation.
Exclusion Criteria:
- Participant is under age 18.
- Participant is unwilling to sign consent.
- Participant is unable to exercise (bedridden or wheel chair bound).
- Participant is enrolled in another study deemed by the investigator to affect oxygen metabolic efficiency and not presently the standard of care at MDACC.
- Participant's condition is deemed unsatisfactory for surgery after the preanesthetic evaluation.
- Participant has had a myocardial infarction within three months of the preanesthetic evaluation or presents with new or unstable angina.
- Participant has a history of a cerebrovascular accident or transit ischemic attacks within three months of the preanesthetic evaluation.
- Participant has a history of a pulmonary embolic event within three months of the preanesthetic evaluation.
- Participant is known to have acute or chronic deep vein thrombosis.
- Participant is pregnant.