Overview
The aim of this study is to report the proportion of patients with acute hypoxemic respiratory failyre (AHRF) undergoing mechanical ventilation who exceed 17 J/min of mechanical power (MP) and the difference in terms of proinflammatory cytokine concentration in blood samples and bronchoalveolar lavage.
The main questions it aims to answer are:
- Which is the proportion of patients who exceed 17 J/min of mechanical power (MP) during the first 72 hours of mechanical ventilation?
- Is there a difference in terms of cytokine concentration in patients undergoing mechanical power >17 J/min compared to <17 J/min?
Patients will be divided into two groups based on respiratory mechanics measurements: low MP group (average MP <17 J/min) and high MP group (average MP ≥17 J/min). The researchers will collect blood and BAL samples and perform cytokine assays.
Eligibility
Inclusion Criteria:
- Patients with AHRF (P/F <300 mmHg) undergoing invasive mechanical ventilation within 7 days from the onset of symptoms
- Invasive mechanical ventilation for less than 6 hours
- Evidence of newly developed lung consolidation on chest imaging (X-ray, CT)
- Age ≥18 years
Exclusion Criteria:
- Prior invasive mechanical ventilation during the same hospitalization
- Tracheostomy
- Severe anemia (Hb<7g/dL)
- Severe neutropenia
- Renal insufficiency or RRT (Renal Replacement Therapy)
- Noradrenaline >0.5 mcg/kg/min
- Pregnancy
- Extracorporeal circulation (ECCO2R, ECMO)
- Life expectancy <24 hours as clinically judged
- Lack of consent