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Determining the Mechanisms of Loss of CAR T Cell Persistence

Determining the Mechanisms of Loss of CAR T Cell Persistence

Recruiting
25 years and younger
All
Phase N/A
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Overview

A prospective observational study of pediatric and young adult acute lymphoblastic leukaemia (ALL) patients treated with CD19 chimeric antigen receptor T-cells (CAR-T cells). The study will examine changes in CAR-T persistence over time and causal factors.

Eligibility

Inclusion Criteria:

  1. Children and young adults (age 25 years or younger) with relapsed/refractory ALL who are planned to receive licensed CD19-targeted CAR-T cell treatment (Tisagenlecleucel)
  2. Written informed consent

Exclusion Criteria:

  1. Patients receiving an alternate CD19-directed CAR T-cell product on a clinical trial
  2. Any reason that in the opinion of the investigator, patients won't be able to adhere to the protocol

Study details
    Acute Lymphoblastic Leukemia With Failed Remission
    Acute Lymphoblastic Leukemia Not Having Achieved Remission
    Acute Lymphoblastic Leukemia
    Pediatric
    Acute Lymphoblastic Leukemia
    Adult
    Acute Lymphoblastic Leukemia
    in Relapse

NCT05809284

University College, London

1 June 2024

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