Overview
This clinical trial evaluates the use of a tool kit, Stress, Affect, Language and Speech Analysis (SALSA), for early identification of cognitive side effects of immunotherapy compared to the standard of care assessment.
Description
PRIMARY OBJECTIVES:
I. To investigate the use of a toolkit for automated administration and scoring of cognitive tests (Stress, Language and Speech Analysis, or SALSA) in adult cancer patients who are treated with commercial chimeric antigen receptor T cell therapy (CAR-T) products at University of Minnesota and are at risk of developing immune effector cell-associated neurotoxicity syndrome (ICANS).
OUTLINE: This is an observational study.
Patients complete SALSA assessment and ICE assessments on study. Patients also have their medical records reviewed on study.
Eligibility
Inclusion Criteria:
- * ≥ 18 years of age at initiation of therapy
- Planning to undergo inpatient CAR-T therapy for primary malignancy
- Fluent in English (written or spoken)
Exclusion Criteria:
- * Subjects with speech or hearing impediment that would make them unable to be
assessed with SALSA
- Subjects with diagnosed cognitive impairment prior to CAR-T therapy
- Unwilling or unable to sign voluntary written consent