Overview

This study will assess the immunogenicity, safety and reactogenicity of the RSVPreF3 OA investigational vaccine when it is co-administered with a COVID-19 messenger ribonucleic acid (mRNA) vaccine (Omicron XBB.1.5), compared to administration of the vaccines separately in adults aged 50 years and above.

Eligibility

Inclusion Criteria:

        • Participants, who, in the opinion of the investigator, can and will comply with the
        requirements of the protocol (e.g., completion of the diary cards, return for follow-up
        visits).
        Note: In case of physical incapacity that would preclude the self-completion of the diary
        cards, either site staff can assist the participant (for activities performed during site
        visits) or the participant may assign a caregiver to assist him/her with this activity (for
        activities performed at home). However, at no time will the site staff or caregiver
        evaluate the participant's health status while answering diaries or make decisions on
        behalf of the participant.
          -  Written or witnessed informed consent obtained from the participant (participant must
             be able to understand the informed consent) prior to performance of any study-specific
             procedure.
          -  A male/female of ≥50 Years of age (YOA) at the time of the first study intervention
             administration.
          -  Participants who are medically stable in the opinion of the investigator at the time
             of first vaccination. Participants with chronic stable medical conditions with or
             without specific treatment, such as diabetes, hypertension or cardiac disease, are
             allowed to participate in this study if considered by the investigator as medically
             stable.
        A stable medical condition is defined as disease not requiring significant change in
        therapy or hospitalization for worsening disease during the 3 months before enrollment.
        • Participants living in the general community or in an assisted-living facility that
        provides minimal assistance, such that the participant is primarily responsible for
        self-care and activities of daily living.
        Participants who have received previously a SARS-CoV-2 vaccine, being administered at least
        3 months prior to study vaccination.
          -  Female participants of non-childbearing potential may be enrolled in the study. Non
             childbearing potential is defined as hysterectomy, bilateral oophorectomy, bilateral
             salpingectomy, and post-menopause.
          -  Female participants of childbearing potential may be enrolled in the study if the
             participant.
               -  has practiced adequate contraception from 1 month prior to study intervention
                  administration and agreed to continue adequate contraception for at least 1 month
                  after the last vaccination.
               -  has a negative pregnancy test on the day of and prior to study intervention
                  administration.
        Exclusion Criteria:
        Medical Conditions
          -  History of any reaction or hypersensitivity likely to be exacerbated by any component
             of the study interventions, including a known history of severe allergic reaction
             (e.g., anaphylaxis).
          -  Any confirmed or suspected immunosuppressive or immunodeficient condition, resulting
             from disease (e.g., current malignancy, human immunodeficiency virus) or
             immunosuppressive/cytotoxic therapy (e.g., medication used during cancer chemotherapy,
             organ transplantation, or to treat autoimmune disorders), based on medical history and
             physical examination (no laboratory testing required).
          -  Any history of myocarditis or pericarditis.
          -  Recurrent history or uncontrolled neurological disorders or seizures. Participants
             with medically-controlled active or chronic neurological diseases can be enrolled in
             the study as per investigator assessment, provided that their condition will allow
             them to comply with the requirements of the protocol (e.g. completion of diary cards,
             attend regular phone calls/study site visits).
          -  Serious or unstable chronic illness.
          -  Any history of dementia or any medical condition that moderately or severely impairs
             cognition.
          -  Significant underlying illness that in the opinion of the investigator would be
             expected to prevent completion of the study (e.g., life-threatening disease likely to
             limit survival up to study end).
          -  Any medical condition that in the judgment of the investigator would make
             intramuscular injection unsafe.
          -  Any SAE attributed to a previous dose of the SARS-CoV-2 mRNA vaccine.
          -  Any other clinical condition that, in the opinion of the investigator, might pose
             additional risk to the participant due to participation in the study.
          -  Recent SARS-CoV-2 infection within 3 months prior to the COVID-19 vaccine dose
             administration. Timelines to be determined from symptoms onset or positive COVID-19
             test (if infection was asymptomatic).
        Prior/Concomitant Therapy Use of any investigational or non-registered product (drug,
        vaccine or invasive medical device) other than the study interventions during the period
        beginning 30 days before the first dose of study interventions and ending 30 days after the
        last vaccine administration, or their planned use during the study period.
          -  Planned administration of a vaccine in the period starting 30 days before the first
             dose and ending 30 days after the last dose of study intervention(s) administration*,
             with the exception of inactivated and subunit influenza vaccines which can be
             administered up to 14 days before or from 14 days after the study vaccination.
             *If emergency mass vaccination for an unforeseen public health threat (e.g., a
             pandemic) is recommended and/or organized by public health authorities outside the
             routine immunization program, the time period described above can be reduced if
             necessary for that vaccine, provided it is used according to the local governmental
             recommendations and Sponsor is notified.
          -  Chronic administration of immune-modifying drugs (defined as more than 14 consecutive
             days in total) and/or planned use of long-acting immune-modifying treatments at any
             time up to the last blood sampling visit.
               -  Up to 3 months prior to the study intervention administration:
                    -  For corticosteroids, this will mean prednisone equivalent ≥ 20 mg/day.
                       Inhaled and topical steroids are allowed.
                    -  Administration of immunoglobulins and/or any blood products or plasma
                       derivatives.
               -  Up to 6 months prior to study intervention administration: long-acting immune
                  modifying drugs including among others immunotherapy (e.g., TNF-inhibitors),
                  monoclonal antibodies and antitumoral medication.
          -  Administration of any SARS-CoV-2 vaccine during the 3 months preceding the study
             COVID-19 mRNA vaccine administration.
          -  Previous vaccination with licensed or investigational RSV vaccine. Prior/Concurrent
             Clinical Study Experience
          -  Concurrently participating in another clinical study, at any time during the study
             period, in which the participant has been or will be exposed to an investigational or
             a non-investigational intervention (drug/invasive medical device).
        Other Exclusion Criteria
          -  Pregnant or lactating female participant.
          -  Female participant planning to become pregnant or planning to discontinue
             contraceptive precautions.
          -  History of chronic alcohol consumption and/or drug abuse as deemed by the investigator
             to render the potential participant unable/unlikely to provide accurate safety reports
             or comply with study procedures.
          -  Participation of any study personnel or their immediate dependents, family, or
             household members.
          -  Planned move during the study conduct that prohibits participation until study end.
          -  Bedridden participants.