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Influence of Positive-End-Expiratory-Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Children

Influence of Positive-End-Expiratory-Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Children

Non Recruiting
1-5 years
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

Interventional Trial to determine the Effect of different PEEP levels on Cardiac output and right-ventricular function in mechanically ventilated children < 5 years of age with congenital heart disease.

Description

Different PEEP-levels will be applied during invasive mechanical ventilation to describe Cardio-pulmonary interactions in children with congenital heart disease (CHD). An additional trial with the same study protocol is planned in a cohort of children with primarily pulmonary disease without CHD after completion of this trial. Esophageal pressure-monitoring, Ultrasound, respiratory mechanics and electrical impedance tomography will be used

Eligibility

Inclusion Criteria:

  • invasive mechanical ventilation
  • congenital heart disease (biventricular anatomy)

Exclusion Criteria:

  • univentricular hearts
  • ECMO/VAD

Study details
    Ventilation Therapy; Complications
    Congenital Heart Disease
    Children
    Only
    Hemodynamic Instability

NCT06270485

Charite University, Berlin, Germany

20 August 2025

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