Overview
The purpose of this study is to assess the association of misuse of hormonal implant with gestrinone in cardiovascular health outcomes in young women.
Description
After being informed about the study, volunteers will be screened in accordance with eligibility criteria. Eligible volunteers will be invited to appear to the research institute and participate in the study. All volunteers giving the written informed consent will perform all assessments in the same day at their visit.
Eligibility
Inclusion Criteria:
- Women;
- Between 25 and 45 years age;
- History of ≥ 1 hormonal implant with gestrinone in the last 6 months or never had used any hormonal implants.
Exclusion Criteria:
- Pregnancy;
- Menopause;
- Smoking;
- Moderate-high consumption of alcoholic beverages (> 14 drinks per week);
- Previous cardiovascular event (e.g. myocardial infarction and stroke);
- Cardiovascular disease (e.g. ischemic heart disease and heart failure);
- Pulmonary disease;
- Metabolic disease;
- Uncontrolled psychiatric disease;
- Endometriosis diagnosis;
- Ventricular arrhythmia;
- Using antibiotics or corticoids;
- Regular contraceptive use (estrogen and progesterone);
- Use of illicit drugs;
- Use of medications for cardiovascular disease (e.g. antihypertensive drugs).