Overview
The purpose of this study is to o determine whether the modified LP procedure reduces the incidence of PLPH to 5% or lower, to determine whether the modified LP procedure reduces the frequency of epidural blood patch (EBP) usage to 10% or lower of the PLPH population and to identify factors that may contribute to or reduce incidence of PLPH
Eligibility
Inclusion Criteria:
- Participants who can sign informed consent
- Participants who have stated willingness to comply with all study procedures and availability for the duration of the study
- Participants receiving a LP per standard of care (SOC) need for diagnostic or therapeutic purposes only
- Participants with Karnofsky Performance Scale (KPS) ≥ 60
Exclusion Criteria:
- Participants with a past medical history of chronic headaches (≥15 days per month) or acute headaches
- Participants with recent neurosurgical device implants such as ventriculoperitoneal shunt
- Participants with more than one dural puncture during the same LP procedure
- Participants have chronic coagulopathy with elevated prothrombin time (PT), Partial thromboplastin time (PTT), and International Normalized ration (INR).
- Participants who are on active anticoagulant or antiplatelet therapy unless stopped such therapy prior to LP per SOC guidance.
- Participants with suspicions of raised intracranial pressure by either clinical assessment or imaging assessment or both
- Participants with severe spinal column deformities, such as scoliosis. Disc diseases are not exclusion criteria
- Participants with LP procedural complications that require a needle type or needle size change