Overview
The investigators aim to study the predictive value of presepsin in ascites in newly admitted patients with chronic liver failure.
Description
Presepsin is a plasmatic cleaved fragment of CD14. CD14 is a toll like receptor who has the role to identify certain lipopolysaccharides on the surface of bacteria (aerobes and anaerobes), thus promoting an inflammatory response.
A study of 153 patients with liver cirrhosis published by a team of investigators from Iasi, Romania, has proven an useful role of plasma presepsin in early diagnosis of infections in patients in acute on chronic liver failure.
In addition, plasma presepsin has been proposed as an independent predictor of mortality in patients with decompensated liver cirrhosis, without concomitant bacterial infections.
Question to be answered by this study The investigators aim to evaluate the predictive role of ascites presepsin in patients with chronic liver failure.
Hypothesis Presepsin levels in ascites may have a prognostic role in patients with ascites and chronic liver failure.
Eligibility
Inclusion Criteria:
- patient with ascites and chronic liver failure
- no contraindications and technical possibility to perform diagnostic paracentesis
- age above 18 years old
- informed consent
Exclusion Criteria:
- contraindications to paracentesis or technical impossibility to perform paracentesis
- absence of informed consent