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Latent TGF-β-binding Proteins Affect the Fibrotic Process in Renal Impairment and Cardiac Dysfunction

Latent TGF-β-binding Proteins Affect the Fibrotic Process in Renal Impairment and Cardiac Dysfunction

Recruiting
20-80 years
All
Phase N/A
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Overview

The project is planed to explore the impact of LTBP4 and other matrix protein and potentially related biomarkers on renal outcomes, cardiac outcomes and all-cause mortality in patients with suspected acute coronary syndrome (ACS).

Description

The investigators will collect the blood samples from patients with suspect ACS. LTBP4 will be the first matrix protein that are going to understand. Upon hospital arrival, blood samples around 8 ml will be collected and the 2nd collection will be two weeks to one month after the event. The third collection will be one year later. In the between, if any ACS event develop, blood samples will be collected as protocols.

Eligibility

Inclusion Criteria:

  • acute coronary syndrome patients

Exclusion Criteria:

  • cardiogenic shock, pregnancy, end-stage renal disease

Study details
    Acute Coronary Syndrome
    Acute Coronary Syndrome With Renal Dysfunction

NCT04998227

National Taiwan University Hospital

3 May 2024

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