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Comparison of Bladder Pressure Versus Regional Intestinal Tissue Oxygenation in Infants

Recruiting
- 12 years of age
Both
Phase N/A

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Overview

The goal of this clinical trial is to learn more about intestinal regional oxygen saturation measurements made with near-infrared spectroscopy and bladder pressure measurements in infants without risk of intraabdominal hypertension. The main question it aims to answer is if - in comparison to bladder pressure - the regional intestinal oxygen saturation measured with near-infrared spectroscopy is stable in the muscle-relaxed, intubated patients and the awake and non-sedated patient.

In case of participation the bladder pressure and the regional intestinal oxygen saturation (measured with near-infrared spectroscopy) will each be measured once intraoperatively and once postoperatively. Patients included in this study will be undergoing an operation which necessitates muscle-relaxation, as well as an indwelling urinary catheter during the operation and for a short-time thereafter for other reasons than this study.

Eligibility

Inclusion Criteria:

  • Prepped and consented for laparoscopic pyeloplasty or minimal PSARP with perineal or vestibular fistula or lateral thoracotomy for the correction of esophageal atresia
  • Age of 12 months old or less at operation
  • Legal custodian gives consent

Exclusion Criteria:

  • Anterior abdominal wall thickness greater than 12 mm measured on preoperative MRI imaging if available
  • Patients planned for additional intestinal surgeries or non-standard pyeloplasty, e.g. pyeloplasty with nephrostoma
  • Patients planned for laparoscopic pyeloplasty whose intraoperative urine sample shows pathological results
  • Patients with esophageal atresia who experience pulmonary decompensation and need urgent surgery for fistula clipping

Study details

Intraabdominal Hypertension, Abdominal Compartment Syndrome

NCT05971264

University Children's Hospital, Zurich

2 May 2024

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