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Impact Hesperetin in Combination With Sucrose on Blood Glucose Regulation

Recruiting
18 - 45 years of age
Both
Phase N/A

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Overview

The aim of this cross-over intervention study is to investigate the influence of hesperetin applied in combination with sucrose in comparison to an equally sweet-tasting sucrose-only solution and an isocaloric sucrose-only solution on markers of energy metabolism

Description

The study is designed as a randomised cross-over intervention study with three arms. The aim is to investigate the influence of a 10% sucrose solution, corresponding to the sugar content of a conventional soft drink, compared to an equally sweet-tasting 7% sucrose solution in combination with 50 mg/L of the polyphenol hesperetin, and a less sweet 7% sucrose solution w/o hesperetin on time-dependent blood glucose fluctuations and ad libitum energy intake in metabolically healthy male volunteers.

To investigate the underlying mechanisms, the individual appetite score, metabolic and hormonal responses to the interventions and will be measured. In addition, the participants' individual thresholds for sweet taste, preference and consumption for sweet-tasting foods such as sugar and sweeteners, and their body composition will be recorded as potential influencing factors.

Eligibility

Inclusion Criteria:

  • healthy
  • non-smoking
  • normal taste responses towards sweet taste

Exclusion Criteria:

  • pregnancy or breast-feeding
  • regular smokers
  • disturbed glucose and/or lipid metabolism
  • regular intake of medication
  • known allergies against one of the test compounds
  • ageusia alcohol or drug addiction intake of antibiotics within the past 2 months

Study details

Blood Glucose Fluctuations, Hunger

NCT06340087

University of Vienna

1 May 2024

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