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Relationship Between Acute Phase Markers and Post-operative Pain in Laparoscopic Cholecystectomy: An Observational Study

Relationship Between Acute Phase Markers and Post-operative Pain in Laparoscopic Cholecystectomy: An Observational Study

Recruiting
18 years and older
All
Phase N/A

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Overview

Many patients undergoing laparoscopic cholecystectomy are prone to developing acute and chronic post-operative pain.

The aim of the study is to show a possible correlation between pain and acute phase proteins in order to:

  • predict the severity of pain;
  • select most suitable pain relief therapy for the patient.

Description

The day after surgery, some serum markers are determined by a blood sample.

The markers analyzed are:

  • Leukocytes;
  • C-reactive protein (CRP);
  • D-dimer;
  • Fibrinogen;
  • Neutrophil-to-Lymphocyte Ratio (NLR).

Pain level is assessed using the NRS scale at different times:

  • 1st post-operative day;
  • 7th post-operative day;
  • One month after surgery;
  • Three months after surgery;
  • Six months after surgery.

Other data collected for the study are: gender, age, BMI.

Eligibility

Inclusion Criteria:

  • patient undergoing laparoscopic cholecystectomy

Exclusion Criteria:

  • children

Study details
    Post Operative Pain

NCT06375057

University of Roma La Sapienza

30 April 2024

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