Overview
Biomarkers for prognosis of patients with polyneuropathy.
Description
AIM: To investigate biomarkers' use as a prognostic tool in polyneuropathy patients.
STUDY DESIGN: Prospective cohort study of patients with polyneuropathy. METHODS: 200 patients with polyneuropathy will be examined with physical tests, medical examination, questionnaires, and blood biomarkers at baseline and at 1-year follow-up, and 2-year follow-up.
ANALYSIS: The investigators will calculate the odds of disease progression after 2 years depending on biomarkers levels at baseline using multiple logistic regression with sex and age adjustment. Diagnostic performance of the physical tests and biomarkers for prediction of disease progression will be assessed by Receiver Operating Characteristic Curve analysis with the area under the curve.
Eligibility
Inclusion Criteria:
- Minimum 18 years old.
- Diagnosed with polyneuropathy, confirmed by nerve conduction study.
- Can read and understand Danish.
Exclusion Criteria:
- Inability to perform physical tests due to comorbidity not associated to the patient's polyneuropathy.