Overview
CHARGE is a hybrid type I feasibility study to compare a choice architecture intervention for cascade genetic testing to usual care.
Description
CHARGE study contains two arms: Arm 1) Usual care, comprising of standard genetic counseling and education to probands regarding cascade testing; and Arm 2) Direct mailing of a home genetic testing kit to probands' at-risk relatives that can be returned directly to a commercial genetic testing laboratory, including educational information on the importance and cost of cascade testing
Eligibility
Proband Inclusion Criteria:
- Have a newly reported pathogenic or likely pathogenic variant in one or more of the following genes: APC, ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, MLH1, MSH2, MSH6, PMS2, PTEN, TP53
- 18 years of age or older
- English fluency
- Have at least 1 adult living genetically related relative who resides in Texas
Proband Exclusion Criteria:
- Referred for genetic testing by a relative with a pathogenic variant
- Unwilling to be randomized to a study arm
Relative Inclusion Criteria:
- 18 years of age or older
- English fluency
- Residing in Texas