Overview
This study will assess changes in nerve excitability of C-fibers, and changes in sympathetic or parasympathetic tone, when the subject experiences pain and pain relief.
The investigators will continuously measure blood pressure, heart rate, respiration rate, gastric motility, sympathetic skin response and C-fiber excitability while using thermal stimuli before and after an analgesic.
Eligibility
Inclusion Criteria:
- Healthy Participants able to give informed consent.
Exclusion Criteria:
- Chronic pain conditions
- Neurological or Psychiatric disease
- Other major diseases
- Pain medication within the last 24 hours