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Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion

Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion

Non Recruiting
18 years and older
All
Phase 2

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Overview

The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.

Description

Propofol is administered as both low dose and as sole anesthetic in patients with history of PONV and/or motion sickness. But efficacy of one dose over the other is not studied. This study plans to clarify if propofol in low dose is as effective as its administration as sole anesthetic in patients with history of PONV and/or motion sickness

Eligibility

Inclusion Criteria:

  1. Undergoing general anesthesia for elective surgery
  2. Documented history of Patient's self-disclosure of PONV and/or motion sickness during pre-anesthesia discussions
  3. No documented allergy/adverse reaction to propofol
  4. English speaking
  5. At least 18 years of age

Exclusion Criteria:

  1. Any anti-nausea medication taken within 24 hours prior to surgery
  2. Unable to provide consent independently
  3. Allergy or adverse reaction to propofol
  4. Emergency surgery

Study details
    Post-operative Nausea and Vomiting

NCT05759481

Milton S. Hershey Medical Center

20 August 2025

FAQs

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