Overview
Study: observational prospective clinical study. Study population: Subjects over 55 years old with drusen secondary to intermediate AMD.
Recruitment: at the Medical Retinal Consultation from the Ophthalmology Department of CHULC.
Primary outcome: Identifying imaging predictors of iAMD progression.
Description
Individuals will be included consecutively and undergo retinal imaging including Color Fundus photography (CFP), Spectral Domain Optical Coherence Tomography (SD-OCT), OCT-Angiography (OCT-A) using Spectralis OCT, with OCT Angiography Module (Heidelberg Eng. GmbH, Germany), in order to characterize:
- FUNDUS AUTOFLUORESCENCE
- Analyse the correlation between drusen morphology and autofluorescent findings
- Analyse the correlation between outer retinal layers morphology and autofluorescent findings
- Assess anatomic biomarkers of disease progression
- VASCULAR FINDINGS
- Test if choriocapillaris perfusion is disturbed in Intermediate AMD patients;
- Test if retinal capillary plexus perfusion is disturbed in Intermediate AMD patients:
2.1. Analyze superficial retinal capillary plexus (SCP), 2.2. Analyze deep retinal capillary plexus (DCP);
3. Assess if choroidal and retinal vascular changes are related to disease progression.
Eligibility
Inclusion Criteria:
- To verify the existence of drusen secondary to intermediate AMD; Soft, cuticular and reticular pseudo-drusen will be considered.
- Accept and sign the consent.
Exclusion Criteria:
- Patients are excluded if it is not possible to obtain good quality CFP, SD-OCT, OCT-A images, if refractive error is ≥±6D or if there is any evidence of accumulation of extracellular fluid, haemorrhage, exudates or fibrosis.
- Additional exclusion criteria included any history of retinal surgery including laser treatment, signs of diabetic retinopathy, history of retinal vascular occlusion, history of anti-VEGF treatment in the study eye or any signs or history of hereditary retinal or macular dystrophy.