Overview
The goal of this interventional study is to learn about the digestibility of different plant-based proteins in adults (age 18-75) with an ileostomy.
The main questions the study aims to answer are:
- How does the digestibility of proteins in the small intestine differ between different plant-based proteins?
- Which proteins and amino acids are not digested or absorbed in the small intestine and are available for further metabolic processes in the large intestine?
- How do metabolites in the collected content of the ileostomy bag differ after consuming different plant-based proteins?
- Can the in vivo results be compared to results from existing in vitro models?
Participants will consume five different protein meals (oat protein - high bioavailable, oat protein - low bioavailable, pea protein - high bioavailable, pea protein low bioavailable, protein-free meal) on five different study days in a random order. Five hours after consuming the test meals ileostomy bags will be collected and the content will be analysed to answer the above mentioned research questions.
Eligibility
Inclusion Criteria:
- Age: 18 - 75 years
- Body mass index: 18.5 - 30 kg/m2
- (double-loop) Ileostomy with an intact small bowel
- Signed informed consent
Exclusion Criteria:
- Pregnancy or breastfeeding
- Ileostomy < 3 months before the study
- Any clinically significant present or past disease/condition other than colon cancer which in the investigator's opinion could interfere with the results of the trial
- Any clinically significant present or past medication which in the investigator's opinion could interfere with the results of the trial