Overview
The purpose of this study is to understand how ketamine works in the brain to bring about a reduction in OCD symptoms.
Description
The proposed mechanistic trial would be the first to probe the role of ketamine's opioid properties in modulating fronto-striatal circuitry and bringing about reduction of OCD symptoms.
Eligibility
Eligibility Criteria for Participants with OCD:
Inclusion Criteria:
- Ages 18-65
- Meet the criteria for OCD diagnosis
- Failed at least 1 prior trial of standard first-line OCD treatment
- Agree to the following lifestyle modifications: comply with requirements for fasting prior to the Experimental Session, not enroll in any other interventional clinical trials during the duration of the study, and commit to medication study procedures.
- Able to provide informed consent
Exclusion Criteria:
- prior naltrexone or ketamine use/exposure
- Any current or past medical/psychiatric condition that makes participation unsafe in the opinion of the investigator or study physician
- Pregnant or nursing, or able to become pregnant and are not practicing an effective means of birth control
- the presence of metal in the body that is contraindicated for MRI scans
Eligibility Criteria for Healthy Volunteers:
Inclusion Criteria:
- Ages 18-65
- Able to provide informed consent
Exclusion Criteria:
- current or past use of psychotropic medication
- pregnant or nursing females
- the presence of metal in the body that is contraindicated for MRI scans