Image

Application of Concentrated Growth Factors in Alveolar Ridge Preservation

Recruiting
25 - 45 years of age
Both
Phase N/A

Powered by AI

Overview

To explore the role of CGF in the regeneration or preservation of soft and hard tissues during tooth extraction site preservation surgery.

Description

A prospective, randomized controlled trial is designed to explore the role of CGF in the regeneration or preservation of soft and hard tissues in extraction site preservation. Using random number table, 20 patients were randomly divided into 4 groups using different filling materials in the extraction socket and materials for the wound sealing. Group A (5cases): bone powder + collagen membrane; Group B (5 cases): bone powder + collagen membrane + CGF membrane; Group C (5 cases): bone powder mixed CGF gel + collagen membrane + CGF membrane; Group D (5 cases): bone powder + CGF membrane.

Extraction and site preservation surgery were performed by the same physician and clinical follow-up was more than 6 months after surgery. The four groups will be compared on several variables, including the changes in pain score, Landry wound healing index, membrane exposure area, keratinized gingival width, buccolingual gingival width, alveolar crest width and height.

Eligibility

Inclusion Criteria:

        Voluntarily participate in this trial and sign a written informed consent; Patients aged 25
        ≤ age ≤ 45 years; The combination of intraoral and imaging examinations confirms that the
        affected tooth has no preservation value, requires tooth extraction, and the patient is
        willing to use site preservation; No progressive periodontal disease or acute apical
        periodontitis in the affected teeth; No long-term history of oral bisphosphonates; Non
        smoking patients; No systemic diseases such as diabetes and hypertension.
        Exclusion Criteria:
        Patients who have difficulty tolerating surgery; Patients under 25 years old or above 45
        years old; The whole body is accompanied by hypertension, diabetes and other serious
        systemic diseases, which need to be controlled by drugs; Patients who take oral medication
        that affects bone metabolism for at least one month due to the need for disease treatment;
        Patients who take medication that may affect platelet function was used within 3 months due
        to the need for disease treatment; Patients unable to undergo X-ray imaging examination due
        to pregnancy or preparation after site preservation surgery; Patients who Smoke; The apical
        and periodontal inflammation is in the acute phase (purulent phase) Regular follow-up or
        follow-up for more than 6 months is not allowed

Study details

Alveolar Ridge Preservation, Concentrated Growth Factor

NCT06308536

The Fourth Affiliated Hospital of Zhejiang University School of Medicine

22 March 2024

Step 1 Get in touch with the nearest study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact

site

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.